BPPK QUESTION PAPER SET FOR PRACTICE

 SET-1

SECTION-A

 very short answer.                                                                      (2-mark x 10= 20)

1.      Explain pore transport mechanism.

2.       What is first pass effect?

3.      What do you mean by apparent volume of Distribution?

4.      IVIVC

5.       What do you mean by onset of action and AUC ?

6.       What do you mean by rate constant and order of reaction?

7.      Explain loading dose and maintenance dose.

8.       Correlation between surface area and drug absorption.

9.       Compare the linear and nonlinear pharmacokinetics.

10.  Give Michaelis Menten equation.

SECTION –B

Answer any seven of the following questions (short type answers):                     (5 marks x 7 = 35Explain )

1.       Explain the factors affecting drug distribution.

2.      What are the Factors affecting renal excretion of drug.

3.      Explain kinetics of protein binding.

4.      Discuss the kinetics of drug administer through IV infusion in one compartment open model.

5.       What are the methods to enhance dissolution and bioavailability of poorly soluble drugs?

6.      Explain Biotransformation and write about microsomal and non-microsomal enzyme.

7.      Discuss the different methods for measurement of bioavailability.

8.      Write a short note on Blood-brain barrier.

9.      Write short notes  the followings

 a. pH partition hypothesis b. Non linear pharmacokinetics

SECTION –C

Answer any two of the following questions                                                            (10 marks x 2 = 20)

1.       Discuss detail about two-compartment open model for a drug administration as IV Bolous.Give schematic presentation, graphs and equation for the same.

2.       Classify factors influencing absorption of drugs. Explain physicochemical factors in detail.

3.       Define metabolism. Explain phase-1 and phase-II reaction in details.

SET--2

BIOPHARMACEUTICS AND PHARMACOKINETICS

Time : Three hours Maximum: 75 marks

I. Write essays on any TWO questions: (2 x 10 = 20)

1. Enlist various factors influencing drug absorption through GIT. Explain in brief about physicochemical factors.

2. What is elimination? Discuss in brief about the pathways of drug metabolism with suitable examples.

3. a) Explain the concept of compartment model?

b) What are the characteristics of drugs with relevant graphs that show

non-linear pharmacokinetics?

II. Write short answers on any SEVEN questions: (7 x 5 = 35)

4. Compare and contrast active and passive transport of drugs?

5. Write the clinical significance of protein binding of drugs.

6. Explain the kinetics of protein binding of drugs.

7. Explain invitro- invivo correlations.

8. Discuss the calculation of pharmacokinetic parameters from plasma concentration time data.

9. Enlist various study designs used in bioequivalent studies. Discuss about latin square design.

10. How do you calculate loading and maintenance doses?

11. Explain the dose effect kinetics using michaelis- menten equation?

12. Explain any one invitro drug dissolution model.

III. Write short notes on : (10 x 2 = 20)

13.Apparent volume of distribution.

14. Polymorphism in drug absorption.

15.Entero hepatic recycling of drugs.

16.USP type I dissolution apparatus.

17. Compartment and model in pharmacokinetics.

18. Ion- pain transport of drugs.

19.Concept of clearance.

20. Salivary excretion of drugs.

21.Blood brain barrier.

22. First pass metabolism.

SET-3

1.a.Classify different types of Phramacokinetic models.

b.Compare absolute bio-availability and relative bio-availability.

c.Define Non linear pharmacokinetic.

d.Enlist the various methods to enhance the dissolution rate of poorly soluble drugs.

e.Mention the non renal routes of drug excretion of drugs.

f.Define Total clearance.

g.What is the significance of maintaining steady state drug levels in pharmacokinetics ?

h.How do you estimate Km and Vmax ?

i.Define Flip-flop phenomenon and lag time!

j.Compare the linear and Non-linear Pharmacokinetics?

                               SECTION-B

a.What are the assumptions made in developing pH partition hypothesis? What are the limitations of pH partition hypothesis?

b.Explain various methods to enhance dissolution of poorly soluble drugs?

c.Explain Michaelis –Menten equation in determining non-linearity? How do you estimate Km and Vmax?.

                                   SECTION-C

a. Describe the various factors causing non-linearity.

b.Give the kinetics of protein binding along with its clinical significance.

c. How do you determine KE using rate of excretion method from urine data.

d.Explain in brief about multi compartment models?

e.Explain  bioequivalence studies in brief?

f.Write in details about microsomal and non microsomal enzyme.

g.How do you estimate Km and Vmax after I.V bolus administration if drug following non-linear pharmacokinetics?