S.D tutorials

  SET-1 SECTION-A  very short answer.                                                                          (2-mark x 10= 20) 1.         Explain pore transport mechanism. 2.          What is first pass effect? 3.        What do you mean by apparent volume of Distribution? 4.        IVIVC 5.          What do you mean by onset of action and AUC ? 6.          What do you mean by rate constant and order of reaction? 7.        Explain loading dose and maintenance dose. 8.          Correlation between surface area and drug absorption. 9.          Compare the linear and nonlinear pharmacokinetics. 10.    Give Michaelis Menten equation. SECTION –B Answer any seven of the following questions (short type answers) :                       (5 marks x 7 = 35Explain ) 1.          Explain the factors affecting drug distribution. 2.        What are the Factors affecting renal excretion of drug. 3.        Explain kinetics of protein binding. 4.        Discuss the kinetics of drug administer through I

  Difference between Linear and non linear pharmacokinetics LINEARPHARMACOKINETIC a. Change in plasma concentration due to ADME process is proportional to dose of drug administered (single or multiple) b.Follow First order kinetics c. Semilog plot for concentration vs time is super imposable (Principle of superimposition) d.No change in F, Ka, Ke, Vd, Clearance etc. NONLINEAR PHARMACOKINETIC a.Rate process of ADME are dependent on carrier or enzymes having definite capacity and subjected to saturation. b.Change in concentration is no more proportional to dose administered during the total process of ADME. c.Follow First order + Zero order kinetics d.Change in different pharmacokinetic parameters. Stages where non-linearity occurs: Non-linearity can occur at any of the following stage during the fate of drug in body: a.Absorption b.Distribution c.Biotransformation/Metabolism d.Excretion Causes of non-linearity a.During absorption i.Absorption is solubility or dissolution rate limited eg

  Difference between Linear and non linear pharmacokinetics LINEARPHARMACOKINETIC a. Change in plasma concentration due to ADME process is proportional to dose of drug administered (single or multiple) b.Follow First order kinetics c. Semilog plot for concentration vs time is super imposable (Principle of superimposition) d.No change in F, Ka, Ke, Vd, Clearance etc. NONLINEAR PHARMACOKINETIC a.Rate process of ADME are dependent on carrier or enzymes having definite capacity and subjected to saturation. b.Change in concentration is no more proportional to dose administered during the total process of ADME. c.Follow First order + Zero order kinetics d.Change in different pharmacokinetic parameters. Stages where non-linearity occurs: Non-linearity can occur at any of the following stage during the fate of drug in body: a.Absorption b.Distribution c.Biotransformation/Metabolism d.Excretion Causes of non-linearity a.During absorption i.Absorption is solubility or dissolution rate limited eg